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GENOME
INSTRUMENTATION RESEARCH
The Human Genome Program is a coordinated, multi disciplinary, goal oriented
research effort aimed at developing technologies that will lead to a detailed understanding of the
human genome at the molecular level. The Medical Applications and Biophysical Research
Division plans and manages research to develop (1) advanced sequencing technologies that will
enable sequencing rates up to one million bases per day and (2) automation of all stages of
chromosomes mapping and sequencing for greater efficiency and cost effectiveness. Integrated,
collaborative multi disciplinary approaches are encouraged in this program. Research on new
sequencing technology includes development of advanced, highly multiplexed capillary gel
electrophoresis systems, electrophoresis separations in liquid media without gels, and applications
of mass spectrometry and flow cytometry to analysis of sequencing fragments. Robotic systems
are being applied in sample preparation procedures, replication of DNA by the polymerase chain
reaction, and synthesis of oligonucleotide arrays. This program is being redirected and program
notices initiating grant applications may be issued during F.Y. 1998.
Roland F. Hirsch, Ph.D
e-mail: roland.hirsch@oer.doe.gov
Charles Edmonds, Ph.D
e-mail: charles.edmonds@oer.doe.gov