The first round of restructuring the Health Effects Research Program is nearly complete with the funding of approximately $15 million in new research at National Laboratories and universities. Six review panels reviewed more than 150 proposals. The following is a summary of projects that have been identified for funding to date.

Microbial Genome - developing methods to more rapidly sequence microbial genomes, to identify a greater diversity of potentially useful microbes, and to mine the rich biochemical potential of microbes for producing and using energy or helping cleanup the environment.

ANL	Giometti	Exploring Whole Genome Sequence Information for Defining the Functions of Unknown Genes and Regulatory Networks in Dissimilatory Metal Reduction Pathways
LLNL	Andersen	Pangenomic Analysis Using RDA
LANL	Kuske	Identification, Isolation, and Genome Amplification of Abundant Non-cultured Bacteria from Novel Phylogenetic Kingdoms in Two Extreme Surface Environments
ORNL	Zhou	Exploring Whole Genome Sequence Information for Defining the Functions of Unknown Genes and Regulatory Networks in Dissimilatory Metal Reduction Pathways

Model Organisms - exploiting the rich diversity of biological and genomic information in model organisms to more quickly understand the organization, function and control of the human genome.

LBNL	Bissell	Interaction of Genome and Cellular Mircoenvironment: How One-dimensional (Linear Sequence) Information Is Selectively Utilized to Make a 3-D (Complex) Tissue
LLNL	Stubbs	Comparative Analysis of Gene Organization, Function, and Regulation in an Imprinted Region of Mouse Chromosome 7 and Related Segments of Human Chromosome 19
LLNL	Thelen	Understanding DNA Repair Mechanisms Through Comparative Genomics
ORNL	Rinchik	Mouse Genetics and Mutagenesis for Functional Genomics
UC Berkeley	Rubin	Resources for Biological Annotation of the Drosophila Genome
UCLA	Hawley	Obtaining the Complete Set of DNA Repair Genes from Drosophila
UCLA	Lake	Automated Methods for Interspecies Analyses of Syntenic Blocks
U Utah	Gesteland	Genomic Analysis of the Multiplicity of Protein Products from Genes

Low Dose Effects -understanding the health impacts of exposures to low doses and low dose rates of energy-related materials and by-products.

LBNL	Cooper	DNA Damage Responses to Low Dose Ionzing Radiation
LBNL	Barcellos-Hoff	Mechanisms of Tissue Response to Low Dose Ionizing Radiation Exposures: Bioinformatic Tools for Multiparametric Analysis of Tissue Radiation DNA Damage Responses to Low Dose Ionzing Radiation
LLNL	Thompson	Assessing Biological Function of DNA-Damage Response Genes
LLNL	Wyrobek	Molecular Mechanisms and Cellular Consequences of Low-dose Exposures to DNA-Damaging Agents
LLNL	Mohrenweiser	DNA Repair Gene Variants: Understanding Mechanisms of Cellular Response and Estimating Individual Health Risk from Low-Dose Radiation Exposure
Brandeis	Haber	Analysis of Gene Targeting and Nonhomologous End-Joining
Case Western	Boothman	Nuclear ApoJ: A Low Dose Radiation Inducible Regulator of Cell Death
Cincinnati	Aronow	(collaborator on Boothman project)
Columbia	Brenner	Genetic, Cytogenetic, and Oncogenic Effects of Low Doses of Low Energy (<50 keV) Xrays
Columbia	Geard	Site Specific Microbeam Irratiation: Defining a Bystander Effect
Harvard	Little	Effects of Low-dose Alpha Irradiation: The Role of Induced Genes and the Bystander Effect
Lovelace	Scott	Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low-dose, Low-dose-rate Exposures
NIH	Fornace	Development of a Functional Genomics Approach Employing Radiation Induced Changes in Gene Expression
N. Carolina	Bloom	The Impact of Human Genes and Their Homologues on the Dynamics of Broken Chromsomes in Yeast
S. Carolina	Hoel	Radiation Leukemogenesis: Applying Basic Science to Epdemiological Estimates of Low Dose Risks and Dose-rate Effects
Texas	Cornforth	Current Cytogenetic Issues Pertaining to Low Dose and Low Dose Rate
U. Modena	Saltini	Functional and Structural Basis of Genetic Susceptibility to Beryllium Hypersensitivity and Progression to Chronic Beryllium Disease

Technology Development - developing methods that will contribute to the high throughput determination of protein structure and function.

LBNL	Kim	Structural Genomics: a Foundation for Functional Genomics
LANL	Cary	High Resolution Atomic Force Microscopy for the Rapid Determination of Three-Dimensional Macromolecular Structure
LANL	Trewhella	Biosynthetic Approaches to Isotope Enrichment for Applications in Neutron Scattering and High Field NMR Spectroscopy
LANL	Terwilliger	High-Throughput Structural Proteomics